货号 |
bsm-54413R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Bub3 antibody |
中文名称 |
Rabbit Anti-Bub3 antibody |
产品标签 |
重组兔单抗 |
研究领域 |
细胞生物,细胞周期蛋白,细胞分化, |
英文别名 |
BUB 3; BUB 3L; BUB3 (budding uninhibited by benzimidazoles 3, yeast) homolog; bub3; BUB3 budding uninhibited by benzimidazoles 3 homolog; BUB3_HUMAN; BUB3L; Budding uninhibited by benomyl; Budding uninhibited by benzimidazoles 3; Budding uninhibited by be |
反应物种(已验证) |
Human,Mouse,Rat |
产品应用(已验证) |
WB,IHC |
产品应用(可推荐) |
ICC,IF,IP |
推荐稀释比例 |
WB=1:500-2000,IP=1:20-50,IHC-P=1:50-200,IHC-F=1:50-200,IF=1:50-200,ICC=1:50-200, |
克隆类型 |
单克隆 |
克隆号 |
24D1 |
抗体来源 |
Rabbit |
理论分子量 |
36 |
细胞定位 |
细胞核 |
性状 |
Liquid |
免疫原 |
Recombinant human Bub3 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus. Chromosome, centromere, kinetochore (By similarity). |
SIMILARITY |
Belongs to the WD repeat BUB3 family. Contains 5 WD repeats. |
SUBUNIT |
Interacts with BUB1 and BUBR1. The BUB1/BUB3 complex interacts with MAD1L1. |
Function |
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of B |
Post-translational |
Poly-ADP-ribosylated by PARP1 (By similarity). |
SWISS |
O43684 |
Gene ID |
9184 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. |