货号 |
bsm-52349R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-YY1(Nuclear Loading Control) antibody |
中文名称 |
Rabbit Anti-YY1(Nuclear Loading Control) antibody |
产品标签 |
内参抗体,重组兔单抗 |
研究领域 |
细胞生物,染色质和核信号,神经生物学,信号转导,细胞周期蛋白,转录调节因子,锌指蛋白,表观遗传学, |
英文别名 |
Yin Yang 1; YY1 transcription factor; CF1; Delta; Delta transcription factor; NF E1; NFE1; Transcriptional repressor protein YY1; UCR motif DNA binding protein; UCRBP; Yin and yang 1; Yin Yang 1; Ying Yang 1; YY 1; YY 1 transcription factor; TYY1_HUMAN. |
反应物种(已验证) |
Human,Mouse,Rat |
产品应用(已验证) |
WB,IHC,FCM |
产品应用(可推荐) |
IF,IP |
推荐稀释比例 |
WB=1:500-2000,IP=1:20-100,IHC-P=1:50-200,IHC-F=1:50-200,Flow Cyt=1ug/Test,IF=1:50-200, |
克隆类型 |
单克隆 |
克隆号 |
5F2 |
抗体来源 |
Rabbit |
理论分子量 |
46 |
细胞定位 |
细胞核 |
性状 |
Liquid |
免疫原 |
Recombinant human YY1 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus matrix. Note=Associated with the nuclear matrix. |
SIMILARITY |
Belongs to the YY transcription factor family.
Contains 4 C2H2-type zinc fingers. |
SUBUNIT |
Interacts with YAF2 through the region encompassing the first and second zinc fingers. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Interacts with EED and EZH2; the i |
Function |
Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have |
Post-translational |
Transiently poly-ADP-ribosylated by PARP1 upon DNA damage, with the effect of decreasing affinity of YY1 to its cognate DNA binding sites. |
SWISS |
P25490 |
Gene ID |
7528 |
保存条件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
YY1 is a ubiquitously distributed transcription factor belonging to the GLI Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. |