货号 |
bsm-54219R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Mad2L1 antibody |
中文名称 |
Rabbit Anti-Mad2L1 antibody |
产品标签 |
重组兔单抗 |
研究领域 |
肿瘤,细胞生物,免疫学,细胞周期蛋白 |
英文别名 |
HSMAD2; Human mitotic feedback control protein Madp2 homolog mRNA complete cds; MAD 2; MAD2 like 1; MAD2 mitotic arrest deficient like 1; MAD2B; MAD2L1; Mitotic arrest deficient 2; Mitotic spindle assembly checkpoint protein MAD2A; REV7; MD2L1_HUMAN. |
中文别名 |
有丝分裂阻滞缺陷2样蛋白1重组兔单克隆抗体 |
反应物种(已验证) |
Human |
产品应用(已验证) |
ICC |
产品应用(可推荐) |
WB |
推荐稀释比例 |
WB=1:500-2000,ICC=1:100, |
克隆类型 |
单克隆 |
克隆号 |
6C6 |
抗体来源 |
Rabbit |
理论分子量 |
23 |
细胞定位 |
细胞核,细胞浆 |
性状 |
Lyophilized or Liquid |
免疫原 |
Recombinant human Mad2L1 protein |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus. Chromosome, centromere, kinetochore. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. |
SIMILARITY |
Belongs to the MAD2 family. Contains 1 HORMA domain. |
SUBUNIT |
Monomer and homodimer. Heterotetramer with MAD1L1. Formation of a heterotetrameric core complex containing two molecules each of MAD1L1 and of MAD2L1 promotes binding of another molecule of MAD2L1 to each MAD2L1, resulting in a heterohexamer. Interacts wi |
Function |
Component of the spindle-assembly checkpoint thatprevents the onset of anaphase until all chromosomes are properlyaligned at the metaphase plate. Required for the execution of themitotic checkpoint which monitors the process ofkinetochore-spindle attachme |
Post-translational |
Phosphorylated on multiple serine residues. The level ofphosphorylation varies during the cell cycle and is highest duringmitosis. Phosphorylation abolishes interaction with MAD1L1 andreduces interaction with CDC20. Phosphorylated by NEK2. |
SWISS |
Q13257 |
Gene ID |
4085 |
保存条件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008] |