货号 |
bsm-54094R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-IKB epsilon antibody |
中文名称 |
Rabbit Anti-IKB epsilon antibody |
产品标签 |
重组兔单抗 |
研究领域 |
细胞生物,免疫学,信号转导,转录调节因子 |
英文别名 |
NFKBIE; I kappa B epsilon; IkappaBepsilon; IkB E; IKBE; MGC72568; NF kappa B inhibitor epsilon; NF kappa BIE; NFkappa BIE; NFkappaB inhibitor epsilon; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor epsilon; OTTHUMP00000016522 |
反应物种(已验证) |
Human |
产品应用(已验证) |
WB |
产品应用(可推荐) |
IHC,IP |
推荐稀释比例 |
WB=1:500-1000,IP=1:20-50,IHC-P=1:50-200, |
克隆类型 |
单克隆 |
克隆号 |
7A4 |
抗体来源 |
Rabbit |
理论分子量 |
45 |
细胞定位 |
细胞浆 |
性状 |
Liquid |
免疫原 |
Recombinant human IKB epsilon protein |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm. |
Tissue |
Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages. |
SIMILARITY |
Belongs to the NF-kappa-B inhibitor family.
Contains 6 ANK repeats. |
SUBUNIT |
Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit. |
Function |
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. |
Post-translational |
Serine phosphorylated; followed by proteasome-dependent degradation. |
SWISS |
O00221 |
Gene ID |
4794 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NFKB interaction with other transcription factors, such as STAT, AP1 (JUN), and NFAT. |