货号 |
bsm-54336R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-CAMK4 antibody |
中文名称 |
Rabbit Anti-CAMK4 antibody |
产品标签 |
重组兔单抗 |
研究领域 |
细胞生物,神经生物学,信号转导,转录调节因子,激酶和磷酸酶,表观遗传学, |
英文别名 |
Brain Ca(2+) calmodulin dependent protein kinase type 4; Brain Ca(2+) calmodulin dependent protein kinase type IV; Calcium / calmodulin dependent protein kinase type 4 catalytic chain; Calcium / calmodulin dependent protein kinase type IV catalytic chain; |
反应物种(已验证) |
Human,Mouse,Rat |
产品应用(已验证) |
WB,IHC |
产品应用(可推荐) |
ICC,IF |
推荐稀释比例 |
WB=1:500-2000,IHC-P=1:50-200,IF=1:50-200,ICC=1:50-200, |
克隆类型 |
单克隆 |
克隆号 |
3F11 |
抗体来源 |
Rabbit |
理论分子量 |
55 |
细胞定位 |
细胞核,细胞浆 |
性状 |
Liquid |
免疫原 |
Recombinant protein corresponding to the C-terminus of human CAMK4 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). |
Tissue |
Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue. |
SIMILARITY |
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Contains 1 protein kinase domain. |
SUBUNIT |
Monomer (By similarity). Interacts with protein phosphatase 2A (PPP2CA/PPP2CB); the interaction is mutually exclusive with binding to Ca(2+)/calmodulin. |
Function |
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play piv |
Post-translational |
Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on Ser-12 and Ser-13.
Glycosylation at Ser-189 modulates the phosphorylation of CaMK4 at Thr-200 and negatively regulates its activity towa |
SWISS |
Q16566 |
Gene ID |
814 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Ca2+/calmodulin dependent protein kinase type IV (CAMKIV) belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. |