货号 |
bsm-60235R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Keratin 6 antibody |
中文名称 |
Rabbit Anti-Keratin 6 antibody |
产品标签 |
重组兔单抗 |
研究领域 |
肿瘤,信号转导 |
英文别名 |
Keratin, type II cytoskeletal 6C; KRT6C; Cytokeratin-6C; CK-6C; Cytokeratin-6E; CK-6E; Keratin K6h; Keratin-6C; K6C; Type-II keratin Kb12; KRT6E; K2C6C_HUMAN |
反应物种(已验证) |
Human,Mouse,Rat |
产品应用(已验证) |
WB,IHC,ICC |
产品应用(可推荐) |
IF |
推荐稀释比例 |
WB=1:500-2000,IHC-P=1:100-500,IF=1:50,ICC=1:20-100, |
克隆类型 |
单克隆 |
克隆号 |
B12C5 |
抗体来源 |
Rabbit |
理论分子量 |
60 |
细胞定位 |
细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human Keratin 6 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
Tissue |
Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath. |
SIMILARITY |
Belongs to the intermediate filament family. |
SUBUNIT |
Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17. Interacts with TCHP. |
Function |
There are at least six isoforms of human type II keratin-6 (K6). There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively). |
DISEASE |
Defects in KRT6A are a cause of pachyonychia congenital type 1 (PC1) [MIM:167200]; also known as Jadassohn-Lewandowsky syndrome. PC1 is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (th |
SWISS |
P48668 |
Gene ID |
286887 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jul 2009] |