货号 |
bs-46009P-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Recombinant SARS-Cov-2 Spike RBD protein, C-mFc (HEK293) |
中文名称 |
Recombinant SARS-Cov-2 Spike RBD protein, C-mFc (HEK293) |
英文别名 |
coronavirus spike Protein, 2019-nCoV; cov spike Protein, 2019-nCoV; novel coronavirus RBD Protein, 2019-nCoV; novel coronavirus s1 Protein, 2019-nCoV; novel coronavirus spike Protein, 2019-nCoV; RBD Protein, 2019-nCoV; S1 Protein, 2019-nCoV; pike RBD Prot |
中文别名 |
新冠病毒S蛋白RBD; 新冠S蛋白RBD; SARS-CoV-2 S蛋白RBD; |
理论分子量 |
14.3 |
实际分子量 |
65 kDa |
性状 |
Lyophilized powder |
纯化方法 |
AC |
SWISS |
P0DTC2 |
Gene ID |
43740568 |
保存条件 |
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. The spike is essential for both host specificity and viral infectivity. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate. |
多肽活性 |
Not tested |
序列 |
319-532/1273 |
标签 |
C-mFc |
纯度 |
>95% as determined by Tris-Bis PAGE; >95% as determined by SEC-HPLC |
表达宿主 |
HEK293 cell |