货号 |
bs-0199R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-GFAP antibody |
中文名称 |
Rabbit Anti-GFAP antibody |
研究领域 |
肿瘤,细胞生物,免疫学,神经生物学,信号转导,干细胞,细胞粘附分子,细胞类型标志物(Astrocyte Marker),细胞骨架, |
英文别名 |
Astrocyte Marker; FLJ45472; GFAP; Glial Fibrillary Acidic Protein; Intermediate filament protein; GFAP_HUMAN. |
反应物种(已验证) |
Human,Mouse,Rat |
反应物种(预测) |
Dog,Pig,Cow,Rabbit,Sheep |
产品应用(已验证) |
WB,IHC,IF,FCM |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:200-1000,IHC-F=1:200-1000,Flow Cyt=1μg/Test,IF=1:200-800, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
48 |
细胞定位 |
细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human GFAP |
抗原表位 |
51-150/432 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm. Note=Associated with intermediate filaments. |
Tissue |
Expressed in cells lacking fibronectin. |
SIMILARITY |
Belongs to the intermediate filament family. |
SUBUNIT |
Interacts with SYNM. Isoform 3 interacts with PSEN1 (via N-terminus). |
Function |
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. |
Post-translational |
Phosphorylated by PKN1. |
DISEASE |
Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are |
SWISS |
P14136 |
Gene ID |
2670 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] |