货号 |
bs-0008R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Nestin antibody |
中文名称 |
Rabbit Anti-Nestin antibody |
研究领域 |
肿瘤,心血管,发育生物学,神经生物学,干细胞,细胞类型标志物(Neural Stem Cell Marker),肿瘤细胞生物标志物, |
英文别名 |
ESTM 46; FLJ 21841; FLJ21841; Intermediate filament protein; Nbla00170; Nes; NEST_RAT; Nestin. |
反应物种(已验证) |
Human,Mouse,Rat |
产品应用(已验证) |
IHC,ICC,IF,FCM |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=1μg/Test ,IF=1:100-500,ICC=1:100, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
209 |
细胞定位 |
细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from rat Nestin |
抗原表位 |
681-750/1893 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
cytoplasm |
Tissue |
CNS stem cells. |
SIMILARITY |
Belongs to the intermediate filament family. |
SUBUNIT |
Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, this protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not e |
Function |
Required for brain and eye development (By similarity). Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to dau |
Post-translational |
Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized. |
SWISS |
P21263 |
Gene ID |
25491 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Nestin is a Class VI intermediate filament expressed in the developing central nervous system (CNS) in early embryonic neuroepithelial stem cells. This protein has been widely used as a predominant marker for stem / progenitor cells, glioma cells, and tumor endothelial cells in the mammalian CNS. Furthermore, it is a superior angiogenic marker to evaluate neovascularity of endothelial cells in tumor. |