货号 |
bs-0284R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-IASPP antibody |
中文名称 |
Rabbit Anti-IASPP antibody |
研究领域 |
肿瘤,免疫学,染色质和核信号,信号转导,表观遗传学, |
英文别名 |
IASPP; inhibitor of apoptosis stimulating protein of p53; Inhibitor of ASPP protein; NFkB interacting protein 1; NKIP1; PPP1R13B-like protein; PPP1R13L;
Protein iASPP; protein phosphatase 1 regulatory (inhibitor) subunit 13 like; RAI; RelA-associated inhi |
反应物种(已验证) |
Human,Rat |
反应物种(预测) |
Mouse,Dog,Cow,Sheep,GuineaPig |
产品应用(已验证) |
ICC,FCM |
产品应用(可推荐) |
IHC,IF,ELISA |
推荐稀释比例 |
Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=1μg/Test,IF=1:100-500,ICC=1:100, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
89 |
细胞定位 |
细胞核,细胞浆,细胞外基质 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human IASPP |
抗原表位 |
15-100/828 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic but also nuclear. |
Tissue |
Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. |
SIMILARITY |
Belongs to the ASPP family.
Contains 2 ANK repeats.
Contains 1 SH3 domain. |
SUBUNIT |
Interacts with RELA NF-kappa-B subunit and with SP1 via its C-terminus part. Interacts with p53/TP53, TP63 and TP73. |
Function |
Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 fu |
SWISS |
Q8WUF5 |
Gene ID |
10848 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
iASPP(inhibitor of apoptosis stimulating protein of p53)regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. Belongs to the ASPP family. |