货号 |
bs-1495R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-OCLN antibody |
中文名称 |
Rabbit Anti-OCLN antibody |
研究领域 |
细胞生物,免疫学,转录调节因子,细胞粘附分子, |
英文别名 |
Occludin, Occludin-1; Occludin1; Occludin 1; FLJ08163; BLCPMG; FLJ18079; FLJ77961; FLJ94056; MGC34277; Occludin; OCLN; OCLN_HUMAN; Tight junction protein occludin. |
反应物种(已验证) |
Human |
反应物种(预测) |
Mouse,Rat,Dog,Pig,Cow,Horse,GuineaPig |
产品应用(已验证) |
WB,FCM |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,Flow Cyt=2µg/Test, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
57 |
细胞定位 |
细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from mouse OCLN |
抗原表位 |
431-522/522 |
抗原细胞定位 |
Cytoplasmic |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Membrane; Multi-pass membrane protein. Cell junction, tight junction. |
Tissue |
Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis. |
SIMILARITY |
Belongs to the ELL/occludin family.
Contains 1 MARVEL domain. |
SUBUNIT |
Interacts with TJP1/ZO1 and with VAPA. |
Function |
May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. |
Post-translational |
Phosphorylated upon DNA damage, probably by ATM or ATR. Dephosphorylated by PTPRJ. May be phosphorylated by PKC during translocation to cell-cell contacts. |
SWISS |
Q61146 |
Gene ID |
18260 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
This gene encodes an integral membrane protein which is located at tight junctions. This protein may be involved in the formation and maintenance of the tight junction. The possibility of several alternatively spliced products has been suggested but the full nature of these products has not been described. [provided by RefSeq]. |