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货号 | bs-3079R-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Rabbit Anti-phospho-MCSF Receptor (Tyr923) antibody |
中文名称 | Rabbit Anti-phospho-MCSF Receptor (Tyr923) antibody |
产品标签 | 磷酸化抗体 |
研究领域 | 细胞生物,细胞凋亡 |
英文别名 | MCSF Receptor; C FMS; CD 115; CD115; CD115 antigen; CFMS; Colony stimulating factor 1 receptor; Colony stimulating factor I receptor; CSF 1 R; CSF 1R; CSF-1 receptor; CSF-1-R; CSF1 R; CSF1R; CSF1R_HUMAN; CSFR; FIM 2; FIM2; FMS; FMS proto oncogene; FMS pro |
反应物种(已验证) | Human,Mouse |
产品应用(可推荐) | ELISA |
推荐稀释比例 | Elisa=1:5000-10000, |
克隆类型 | 多克隆 |
抗体来源 | Rabbit |
理论分子量 | 107 |
细胞定位 | 细胞膜 |
性状 | Liquid |
免疫原 | KLH conjugated Synthesised phosphopeptide derived from human CSF1R around the phosphorylation site of Tyr923 |
抗原表位 | RD(p-Y)TN |
抗原细胞定位 | Cytoplasmic |
亚型 | IgG |
纯化方法 | affinity purified by Protein A |
SUBCELLULAR | Cell membrane; Single-pass type I membrane protein. |
Tissue | Expressed in bone marrow and in differentiated blood mononuclear cells. |
SIMILARITY | Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. Contains 5 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain. |
SUBUNIT | Interacts with INPPL1/SHIP2 and THOC5. Monomer. Homodimer. Interacts with CSF1 and IL34. Interaction with dimeric CSF1 or IL34 leads to receptor homodimerization. Interacts (tyrosine phosphorylated) with PLCG2 (via SH2 domain). Interacts (tyrosine phospho |
Function | Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macropha |
Post-translational | Autophosphorylated in response to CSF1 or IL34 binding. Phosphorylation at Tyr-561 is important for normal down-regulation of signaling by ubiquitination, internalization and degradation. Phosphorylation at Tyr-561 and Tyr-809 is important for interaction |
DISEASE | Note=Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers. Note= |
SWISS | P07333 |
Gene ID | 1436 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | This protein tyrosine kinase transmembrane receptor is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a member of the CSF1/PDGF receptor family of tyrosine protein kinases and contains 5 immunoglobulin like C2 type domains. CD115 is expressed by cells of the monocytic lineage and by progenitor cells. Mutations in this gene have been associated with a predisposition to myeloid malignancy. |