货号 |
bs-11496R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-VAX1 antibody |
中文名称 |
Rabbit Anti-VAX1 antibody |
研究领域 |
细胞生物,神经生物学,表观遗传学, |
英文别名 |
VAX1; VAX1_HUMAN; ventral anterior homeobox 1. |
反应物种(已验证) |
Human,Mouse,Rat |
反应物种(预测) |
Chicken,Dog,Pig,Cow |
产品应用(已验证) |
WB,FCM |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,Flow Cyt=0.2μg/Test, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
35 |
细胞定位 |
细胞核 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human VAX1 |
抗原表位 |
133-200/334 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus. |
SIMILARITY |
Belongs to the EMX homeobox family.
Contains 1 homeobox DNA-binding domain. |
Function |
Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk. |
DISEASE |
Defects in VAX1 are the cause of microphthalmia, syndromic, type 11 (MCOPS11) [MIM:614402]. A rare clinical entity including as main characteristics microphthalmia and small optic nerves, cleft lip and palate, absence of corpus callosum, hippocampal malfo |
SWISS |
Q5SQQ9 |
Gene ID |
11023 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and the control of gene expression. VAX1 (ventral anterior homeobox 1) is a 334 amino acid protein that localizes to the nucleus and contains one homeobox DNA-binding domain. Expressed as multiple alternatively spliced isoforms, VAX1 is required for major tract formation and axon guidance in the developing brain and may play a role in the differentiation of various structures, including the optic stalk, the neuroretina and the pigmented epithelium. The gene encoding VAX1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. |