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货号 | bs-2507R-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Rabbit Anti-CD44 antibody |
中文名称 | Rabbit Anti-CD44 antibody |
研究领域 | 肿瘤,细胞生物,免疫学 |
英文别名 | LHR; BA-1; CD 44; CD44 antigen; CD44 molecule; CD44_HUMAN; CDw44; Cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; ECMR-III; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and |
反应物种(已验证) | Human,Mouse |
反应物种(预测) | Rat,Chicken,Pig,Cow,Rabbit |
产品应用(已验证) | FCM |
产品应用(可推荐) | ELISA |
推荐稀释比例 | Elisa=1:5000-10000,Flow Cyt=1μg/Test, |
克隆类型 | 多克隆 |
抗体来源 | Rabbit |
理论分子量 | 53 |
细胞定位 | 细胞膜 |
性状 | Liquid |
免疫原 | KLH conjugated synthetic peptide derived from rat CD44v6 |
抗原表位 | 325-429/429 |
抗原细胞定位 | Cytoplasmic |
亚型 | IgG |
纯化方法 | affinity purified by Protein A |
SUBCELLULAR | Membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges. |
SIMILARITY | Contains 1 Link domain. |
SUBUNIT | Interacts with PKN2. |
Function | Main cell surface receptor for hyaluronate. Adhesion to ucosal high endothelial venule and to types I and VI collagen. robably involved in matrix adhesion, lymphocyte activation and ymph node homing. |
Post-translational | N-glycosylated. O-glycosylated; contains chondroitin sulfate glycans which an be more or less sulfated. Phosphorylated; activation of PKC results in the ephosphorylation of Ser-467 (constitutive phosphorylation site), nd the phosphorylation of Ser |
SWISS | P16070 |
Gene ID | 960 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | CD44 is the receptor for hyaluronic acid (HA). It mediates cell to cell and cell matrix interactions through its affinity for HA. Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. High protein heterogeneity due to several alternative splicing and post translational modification events. CD44R represents a heterogeneous group of CD44 variant isoforms expressed constitutively in epithelial cells and monocyte lineage cells and can be upregulated in activated leukocytes. CD44R, and in particular CD44v6 containing isoforms, may be involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to sites of inflammation. CD44v6 containing isoforms may be involved in tumor metastasis. The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq]. |