货号 |
bs-0006R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Nestin antibody |
中文名称 |
Rabbit Anti-Nestin antibody |
研究领域 |
肿瘤,细胞生物,发育生物学,神经生物学,干细胞,肿瘤细胞生物标志物, |
英文别名 |
ESTM 46; FLJ 21841; FLJ21841; Intermediate filament protein; Nbla00170; Nes; NEST_HUMAN; Nestin. |
反应物种(已验证) |
Human |
产品应用(已验证) |
IHC,ICC,FCM |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
Elisa=1:5000-10000,IHC-P=1:100-500,Flow Cyt=1ug/Test,ICC=1:100, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
178 |
细胞定位 |
细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human Nestin |
抗原表位 |
801-900/1621 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
Tissue |
CNS stem cells. |
SIMILARITY |
Belongs to the intermediate filament family. |
SUBUNIT |
Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, tis protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not ex |
Function |
Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells duri |
Post-translational |
Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized. |
SWISS |
P48681 |
Gene ID |
10763 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
There are a certain number of neural stem cells, which can be potentially differentiated into the neurons or neuroglia, in the adult mammalian brain. These neural precursors are located in the subependymal cell layer of the ventricle. Those precursors isolated from embryonic brain can be divided and differentiated into the neurons and glia in vitro and this is regulated by a series of growth-factor actions. |