货号 |
bs-2132R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Angiotensin II type 1A receptor antibody |
中文名称 |
Rabbit Anti-Angiotensin II type 1A receptor antibody |
研究领域 |
心血管,细胞生物,免疫学 |
英文别名 |
AGTR1; Agtr1a; AT1; AT1A; AT1AR; Type 1 angiotensin II receptor; AGTR1_HUMAN; AGTR1B; AT2R1; AT2R1B. |
反应物种(已验证) |
Human,Mouse,Rat |
产品应用(已验证) |
WB,IHC,FCM |
产品应用(可推荐) |
IF |
推荐稀释比例 |
WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=3ug/Test,IF=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
41 |
细胞定位 |
细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human Angiotensin II type 1A receptor |
抗原表位 |
101-200/359 |
抗原细胞定位 |
Extracellular |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cell membrane; Multi-pass membrane protein. |
Tissue |
Liver, lung, adrenal and adrenocortical adenomas. |
SIMILARITY |
Belongs to the G-protein coupled receptor 1 family. |
SUBUNIT |
Interacts with MAS1 (Probable). Interacts with ARRB1. |
Function |
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
Post-translational |
C-terminal Ser or Thr residues may be phosphorylated. |
DISEASE |
Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter p |
SWISS |
P30556 |
Gene ID |
185 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The Angiotensin II type 1 receptor (AT1) is the primary effector of Angiotensin II, a key regulator of blood pressure and fluid homeostasis. It is involved in pathogenesis of several cardiovascular diseases such as hypertension, cardiac hypertrophy and congestive heart failure. Angiotensin II interacts with two types of G-protein coupled membrane receptors, AT1 (type 1) and AT2 (type 2). AT1 has three isoforms in rodents: AT1A (359 aa), AT1B (359 aa), and AT1C (177 aa). Rat AT1's are predicted to contain seven transmembrane domains. The N-terminus is predicted to be extracellular, while the C-terminus is predicted to be cytoplasmic. AT1's are expressed in the liver, kidney, aorta, lung, uterus, ovary, spleen, heart, adrenal and vascular smooth muscle. |