货号 |
bs-0229R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-FGF1 antibody |
中文名称 |
Rabbit Anti-FGF1 antibody |
研究领域 |
肿瘤,细胞生物,免疫学,生长因子和激素 |
英文别名 |
Acidic fibroblast growth factor;
Acidic-fibroblast growth factor;
aFGF;
Beta endothelial cell growth factor;
Beta-endothelial cell growth factor;
ECGF;
ECGF beta;
ECGF-beta;
ECGFA;
ECGFB;
Endothelial Cell Growth Factor alpha;
Endothelial Cell G |
反应物种(已验证) |
Human,Mouse |
反应物种(预测) |
Rat,Sheep |
产品应用(已验证) |
IHC,ICC,FCM |
产品应用(可推荐) |
IF,ELISA |
推荐稀释比例 |
Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=1ug/Test,IF=1:100-500,ICC=1:100, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
16 |
细胞定位 |
细胞核,细胞浆,细胞膜,分泌型蛋白 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human FGF1 |
抗原表位 |
16-80/155 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A |
Tissue |
Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle. |
SIMILARITY |
Belongs to the heparin-binding growth factors family. |
SUBUNIT |
Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 a |
Function |
The heparin-binding fibroblast growth factors play important roles in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. They are potent mitogens in vitro. |
Post-translational |
In the nucleus, phosphorylated by PKC/PRKCD. |
SWISS |
P05230 |
Gene ID |
2246 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
FGF1 also designated Heparin-binding growth factor 1 precursor (HBGF-1) ; Acidic fibroblast growth factor (aFGF). heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors. Subunit si monomer.FGF1 belongs to the heparin-binding growth factors family. may play a role in neurite outgrowth; may regulate cell differentiation in the nervous system; may act in synergy with fibronectin to enhance neuronal cell adhesion. |