货号 |
bs-10099R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-CYP11A1 antibody |
中文名称 |
Rabbit Anti-CYP11A1 antibody |
研究领域 |
肿瘤,细胞生物,免疫学,转录调节因子,线抗体, |
英文别名 |
Cholesterol 20 22 desmolase;
Cholesterol desmolase;
Cholesterol monooxygenase (side chain cleaving);
Cholesterol side chain cleavage enzyme;
Cholesterol side chain cleavage enzyme mitochondrial;
Cholesterol side-chain cleavage enzyme;
CP11A_HUMAN;
|
反应物种(已验证) |
Human,Mouse,Rat |
反应物种(预测) |
Dog,Pig,Cow,Horse,Rabbit,Sheep,53/57 |
产品应用(已验证) |
WB,IHC,FCM |
产品应用(可推荐) |
ICC,IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=1μg/Test,IF=1:100-500,ICC=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
53/57 |
细胞定位 |
细胞浆,细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human CYP11A1/P450SCC |
抗原表位 |
41-140/521 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Mitochondrion membrane. |
SIMILARITY |
Belongs to the cytochrome P450 family. |
Function |
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone. |
DISEASE |
Defects in CYP11A1 are the cause of adrenal insufficiency congenital with 46,XY sex reversal (AICSR) [MIM:613743]. A rare disorder that can present as acute adrenal insufficiency in infancy or childhood. ACTH and plasma renin activity are elevated and adr |
SWISS |
P05108 |
Gene ID |
1583 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008] |