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货号 | bs-2016R-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Rabbit Anti-Integrin Alpha V + Beta 1 antibody |
中文名称 | Rabbit Anti-Integrin Alpha V + Beta 1 antibody |
研究领域 | 细胞生物,信号转导,细胞膜受体,细胞粘附分子, |
英文别名 | Integrin alpha 5 beta 1; fibronectin receptor alpha; ITGAV; CD51; DKFZp686A08142; MSK8; Msk 8; VNR; similar to Integrin alpha-V precursor; Vitronectin receptor subunit alpha; CD51 antigen; HGNC; Vitronectin receptor alpha polypeptide; Vitronectin receptor |
反应物种(已验证) | Human,Rat |
反应物种(预测) | Mouse,Dog,Pig,Cow,Horse,Sheep |
产品应用(已验证) | WB,FCM |
产品应用(可推荐) | IHC,ELISA |
推荐稀释比例 | WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,Flow Cyt=1μg /test, |
克隆类型 | 多克隆 |
抗体来源 | Rabbit |
理论分子量 | 114 |
细胞定位 | 细胞浆,分泌型蛋白 |
性状 | Liquid |
免疫原 | KLH conjugated synthetic Mixed peptides 915-948/1048(human Integrin αV)+ 21-70/798(human Integrin β1) |
亚型 | IgG |
纯化方法 | affinity purified by Protein A |
SUBCELLULAR | Membrane. |
SIMILARITY | Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats. |
Function | The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In |
SWISS | P06756 |
Gene ID | 3685 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. Integrin alpha 5 belongs to the integrin alpha chain family. It contains seven FG-GAP repeats. Integrin beta 1 belongs to the integrin beta chain family. It contains one VWFA domain. Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein se ems to enhance angiogenesis in Kaposi's sarcoma lesions. |