货号 |
bs-2930R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Frizzled 5 antibody |
中文名称 |
Rabbit Anti-Frizzled 5 antibody |
研究领域 |
肿瘤,细胞生物,免疫学,信号转导,干细胞,G蛋白偶联受体,细胞表面分子,G蛋白信号, |
英文别名 |
C2orf31; DKFZP434E2135; Frizzled homolog 5; Frizzled-5; Frizzled5; Fz 5; Fz-5; Fz5; FZD 5; hFz5; FZD5; FZD5_HUMAN; FzE 5; FzE5; HFZ 5; HFZ5; MGC129692; Seven transmembrane receptor frizzled 5; Uncharacterized protein C2orf31; Wnt receptor. |
反应物种(已验证) |
Human,Mouse |
反应物种(预测) |
Rat,Dog,Pig,Cow,Rabbit |
产品应用(已验证) |
WB,FCM |
产品应用(可推荐) |
IHC,IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=2ug/Test,IF=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
62 |
细胞定位 |
细胞浆,细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human Frizzled 5 |
抗原表位 |
51-150/585 |
抗原细胞定位 |
Extracellular |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. |
SIMILARITY |
Belongs to the G-protein coupled receptor Fz/Smo family. Contains 1 FZ (frizzled) domain. |
SUBUNIT |
Interacts with GOPC (By similarity). |
Function |
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt |
Post-translational |
Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. |
SWISS |
Q13467 |
Gene ID |
7855 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The Frizzled 5 protein is believed to be the receptor for the Wnt5A ligand. Frizzled 5 has been reported to be expressed in fetal kidney, fetal and adult liver, fetal lung, and adult pancreas. ESTs have been isolated from bone, liver/spleen, placenta, and prostate libraries. Frizzled 5 was cloned from a retina cDNA library. |