货号 |
bs-3618R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-HSD11B2 antibody |
中文名称 |
Rabbit Anti-HSD11B2 antibody |
研究领域 |
肿瘤,免疫学,信号转导,细胞凋亡,转录调节因子,激酶和磷酸酶 |
英文别名 |
Corticosteroid 11 beta dehydrogenase isozyme 2; 11 beta HSD2; 11 beta hydroxysteroid dehydrogenase type 2; 11 DH2; AME; AME1; HSD11K; HSD2; Hydroxysteroid 11 beta dehydrogenase 2; Hydroxysteroid 11 beta dehydrogenase isoenzyme 2; NAD dependent 11 beta hyd |
反应物种(已验证) |
Human,Mouse,Rat,Horse |
反应物种(预测) |
Dog |
产品应用(已验证) |
WB,ICC,FCM |
推荐稀释比例 |
WB=1:200-1000,Flow Cyt=1ug/Test,ICC=1:100, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
45 |
细胞定位 |
细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human HSD11B2 |
抗原表位 |
151-250/405 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Microsome. Endoplasmic reticulum. |
Tissue |
Found in placenta, kidney, pancreas, prostate, ovary, small intestine and colon. |
SIMILARITY |
Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
SUBUNIT |
Interacts with ligand-free cytoplasmic NR3C2. |
Function |
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. |
SWISS |
P80365 |
Gene ID |
3291 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010] |