货号 |
bs-2929R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-CD40/TNFRSF5 antibody |
中文名称 |
Rabbit Anti-CD40/TNFRSF5 antibody |
研究领域 |
心血管,细胞生物,免疫学,干细胞,细胞表面分子,淋巴细胞,B-淋巴细胞, |
英文别名 |
Tumor necrosis factor receptor superfamily, member 5; TNFRSF5; B cell associated molecule CD40; B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD 40; CD40 antigen (TNF receptor superfamily member 5); CD40 antig |
反应物种(已验证) |
Human,Mouse,Rat,Rabbit |
反应物种(预测) |
Chicken,Dog,Pig,Cow |
产品应用(已验证) |
WB,IHC |
产品应用(可推荐) |
IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
30 |
细胞定位 |
细胞膜,分泌型蛋白 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human CD40/TNFRSF5. |
抗原表位 |
201-277/277 |
抗原细胞定位 |
Cytoplasmic |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Isoform I: Cell membrane; Single-pass type I membrane protein. Isoform II: Secreted. |
Tissue |
B-cells and in primary carcinomas. |
SIMILARITY |
Contains 4 TNFR-Cys repeats. |
SWISS |
P25942 |
Gene ID |
958 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul2008]. |