货号 |
bs-3122R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Phospho-Cyclin B1 (Ser147) antibody |
中文名称 |
Rabbit Anti-Phospho-Cyclin B1 (Ser147) antibody |
产品标签 |
磷酸化抗体 |
研究领域 |
肿瘤,细胞生物,细胞周期蛋白 |
英文别名 |
Cyclin B1 (phospho S147); Cyclin B1 (phospho-Ser147); p-Cyclin B1 (S147); p-Cyclin B1 (Ser147); p-Cyclin B1 (phospho S147); CCNB 1; CCNB; CCNB1; CCNB1_HUMAN; G2 mitotic specific cyclin B1; G2/mitotic-specific cyclin-B1. |
反应物种(已验证) |
Human |
反应物种(预测) |
Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,GuineaPig |
产品应用(已验证) |
FCM |
产品应用(可推荐) |
WB,IHC,IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=1μg /Test,IF=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
48 |
细胞定位 |
细胞核,细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated Synthesised phosphopeptide derived from human Cyclin B1 around the phosphorylation site of Ser147 |
抗原表位 |
AF(p-S)DV |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome. |
SIMILARITY |
Belongs to the cyclin family. Cyclin AB subfamily. |
SUBUNIT |
Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active |
Function |
Essential for the control of the cell cycle at the G2/M (mitosis) transition. |
Post-translational |
Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases. Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosph |
SWISS |
P14635 |
Gene ID |
891 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008]. |