货号 |
bs-5634R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-phospho-SIRT6 (Ser338) antibody |
中文名称 |
Rabbit Anti-phospho-SIRT6 (Ser338) antibody |
产品标签 |
磷酸化抗体 |
研究领域 |
肿瘤,心血管,免疫学,染色质和核信号,信号转导,细胞凋亡,新陈代谢,表观遗传学, |
英文别名 |
SIRT6(phospho S338); NAD-dependent protein deacylase sirtuin-6; SIR2L6; EC:2.3.1.-; NAD-dependent protein deacetylase sirtuin-6; Protein mono-ADP-ribosyltransferase sirtuin-6; Regulatory protein SIR2 homolog 6; SIR2-like protein 6; SIR6_HUMAN; |
反应物种(已验证) |
Human |
产品应用(已验证) |
IHC,ICC |
产品应用(可推荐) |
WB,IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
39 |
细胞定位 |
细胞核 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthesised phosphopeptide derived from human SIRT6 around the phosphorylation site of Ser338 |
抗原表位 |
PT(p-S)PA |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus, nucleoplasm. |
SIMILARITY |
Belongs to the sirtuin family. Class IV subfamily. Contains 1 deacetylase sirtuin-type domain. |
SUBUNIT |
Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8. |
Function |
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and |
SWISS |
Q8N6T7 |
Gene ID |
51548 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein. |