货号 |
bs-1252R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-API5 antibody |
中文名称 |
Rabbit Anti-API5 antibody |
研究领域 |
肿瘤,免疫学,细胞凋亡 |
英文别名 |
apoptosis inhibitor 5; apoptosis inhibitory protein 5; API5; AAC-11; AAC11; API5L1; AAC 11; Antiapoptosis clone 11 protein; API5 like 1; Cell migration inducing gene 8 protein; Fibroblast growth factor 2 interacting factor 2; FIF; Migration inducing prote |
反应物种(已验证) |
Mouse,Rat |
反应物种(预测) |
Human,Dog,Pig,Cow,Horse,GuineaPig |
产品应用(已验证) |
WB,IHC |
推荐稀释比例 |
WB=1:500-2000,IHC-P=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
57 |
细胞定位 |
细胞核,细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human API5 |
抗原表位 |
351-460/504 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus. Cytoplasm. Note=Mainly nuclear. Can also be cytoplasmic. Isoform 3: Cytoplasm. |
Tissue |
Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma |
SIMILARITY |
Belongs to the API5 family. |
SUBUNIT |
Monomer. Interacts with FGF2 and ACIN1. |
Function |
Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its de |
Post-translational |
Acetylation at Lys-251 impairs antiapoptotic function. |
SWISS |
Q9BZZ5 |
Gene ID |
8539 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Apoptosis inhibitor 5 (API5) is an antiapoptotic factor which may have a role in protein assembly. API5 expression is often upregulated in tumor cells, particularly in metastatic cells. It is a critical determinant of E2F1-induced apoptosis, acting downstream of E2F to suppress E2F-dependent apoptosis without generally blocking E2F-dependent transcription. Alternate Names: AAC 11; AAC11; Antiapoptosis clone 11 protein; API 5; API5; API5 like 1; API5L1; Cell migration inducing gene 8 protein; Fibroblast growth factor 2 interacting factor 2; FIF; MIG 8; MIG8; Migration inducing protein MIG8; Protein XAGL. |