货号 |
bs-3886R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-NCF1 antibody |
中文名称 |
Rabbit Anti-NCF1 antibody |
研究领域 |
肿瘤,细胞生物,免疫学,新陈代谢, |
英文别名 |
47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NADPH oxidase organizer 2; NCF 47K; NCF-1; NCF-47K; Ncf1; NCF1_HUMAN; Neutrophil cytosol factor 1; Neutrophil cytosolic factor 1; Neutrophil NADPH oxidase factor 1; |
反应物种(已验证) |
Human,Mouse |
反应物种(预测) |
Rat,Dog |
产品应用(已验证) |
WB,FCM |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,Flow Cyt=1ug/test, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
45 |
细胞定位 |
细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human NCF1 |
抗原表位 |
151-250/390 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm. |
SIMILARITY |
Contains 1 PX (phox homology) domain. Contains 2 SH3 domains. |
SUBUNIT |
Interacts with NOXA1. Interacts with ADAM15. Interacts with TRAF4. Interacts with FASLG. |
Function |
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). |
Post-translational |
Phosphorylated by PRKCD; phosphorylation induces activation of NCF1 and NADPH oxidase activity. |
DISEASE |
Granulomatous disease, chronic, cytochrome-b-positive 1, autosomal recessive (CGD1) [MIM:233700]: A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacte |
SWISS |
P14598 |
Gene ID |
653361 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
NCF1, along with NCF2 and a membrane bound cytochrome b558, is required for activation of the latent NADPH oxidase necessary for superoxide production. Defects in NCF1 are the cause of autosomal cytochrome-b-positive chronic granulomatous disease type 1 (CGD). |