货号 |
bs-3477R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Phospho-YB1 (Ser102) antibody |
中文名称 |
Rabbit Anti-Phospho-YB1 (Ser102) antibody |
产品标签 |
磷酸化抗体 |
研究领域 |
肿瘤,细胞生物,免疫学,信号转导,转录调节因子 |
英文别名 |
Y box-binding protein1; nuclease sensitive element binding protein 1; YB1; BP-8; CSDB; DBPB; YB-1; CSDA2; NSEP1; NSEP-1; MDR-NF1; MGC104858; MGC110976; MGC117250; YBX1; CCAAT binding transcription factor I subunit A; DNA binding protein B; major histocomp |
中文别名 |
DNA结合蛋白B; y-盒结合蛋白1; |
反应物种(已验证) |
Human,Mouse,Rat |
反应物种(预测) |
Chicken,Dog,Pig,Cow,Horse,Rabbit,GuineaPig |
产品应用(已验证) |
WB,IHC |
产品应用(可推荐) |
IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
36 |
细胞定位 |
细胞核,细胞浆,分泌型蛋白 |
性状 |
Liquid |
免疫原 |
KLH conjugated Synthesised phosphopeptide derived from human YB1 around the phosphorylation site of Ser102 |
抗原表位 |
LR(p-S)VG |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm. Nucleus. Cytoplasmic granule. Secreted. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance |
SIMILARITY |
Contains 1 CSD (cold-shock) domain. |
SUBUNIT |
Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (By similarity). Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. Identified i |
Function |
Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA an |
Post-translational |
Ubiquitinated by RBBP6; leading to a decrease of YBX1 transcactivational ability. In the absence of phosphorylation the protein is retained in the cytoplasm.br
|
SWISS |
P67809 |
Gene ID |
4904 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The Y-box binding protein 1(YB1)is a pluripotent DNA/RNA-binding factor which regulates gene expression through transcription and translation. YB1 has been shown to be a marker of tumour aggressiveness and belongs to the cold-shock domain family. |