货号 |
bs-3250R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Phospho-LKB1 (Thr189) antibody |
中文名称 |
Rabbit Anti-Phospho-LKB1 (Thr189) antibody |
产品标签 |
磷酸化抗体 |
研究领域 |
肿瘤,免疫学,神经生物学,信号转导,细胞凋亡,转录调节因子,激酶和磷酸酶 |
英文别名 |
STK11(phospho T189); LKB1(phospho Thr189); LKB1 (phospho T189); p-LKB1 (phospho T189); p-LKB1(phospho Thr189); p-LKB1(T189); LKB1; PJS; Renal carcinoma antigen NY-REN-19; Serine/Threonine Kinase 11; Serine/threonine protein kinase 11; Serine/threonine pro |
反应物种(已验证) |
Human |
反应物种(预测) |
Mouse,Rat,Pig,Cow |
产品应用(已验证) |
WB |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
48 |
细胞定位 |
细胞核,细胞浆,细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthesised phosphopeptide derived from human LKB1 around the phosphorylation site of Thr189 |
抗原表位 |
G(p-T)LK |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus. Cytoplasm. Membrane. Mitochondrion. Note=A small fraction localizes at membranes. Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to mitochondrion during apoptosi |
Tissue |
Ubiquitously expressed. Strongest expression in testis and fetal liver. |
SIMILARITY |
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily. Contains 1 protein kinase domain. |
SUBUNIT |
Catalytic component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Found in a ternary compl |
Function |
Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts |
Post-translational |
Phosphorylated by ATM at Thr-363 following ionizing radiations (IR). Phosphorylation at Ser-428 by RPS6KA1 and/or some PKA is required to inhibit cell growth. Phosphorylation at Ser-428 is also required during neuronal polarization to mediate phosphorylat |
DISEASE |
Defects in STK11 are a cause of Peutz-Jeghers syndrome
(PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melan |
SWISS |
Q15831 |
Gene ID |
6794 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]. |