货号 |
bs-4573R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-APOA1 antibody |
中文名称 |
Rabbit Anti-APOA1 antibody |
研究领域 |
心血管,神经生物学,信号转导,脂蛋白,新陈代谢, |
英文别名 |
Apo-AI;
ApoA I;
ApoA-I;
APOA1_HUMAN;
Apolipoprotein A-I(1-242);
Apolipoprotein A1;
Apolipoprotein A 1;
Apolipoprotein AI;
Apolipoprotein A I;
Brp14;
Ltw1;
Lvtw1;
Sep1;
Sep2. |
反应物种(已验证) |
Human,Mouse,Rat |
产品应用(已验证) |
WB,IHC |
产品应用(可推荐) |
ICC,IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
28 |
细胞定位 |
分泌型蛋白 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human Apolipoprotein A 1 |
抗原表位 |
45-150/267 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Secreted. |
Tissue |
Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. |
SIMILARITY |
Belongs to the apolipoprotein A1/A4/E family. |
SUBUNIT |
Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. |
Function |
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activat |
Post-translational |
Palmitoylated.
Phosphorylation sites are present in the extracelllular medium. |
DISEASE |
Defects in APOA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) [MIM:604091]; also known as familial hypoalphalipoproteinemia (FHA). Inheritance is autosomal dominant.
Defects in APOA1 are a cause of the low HDL levels observed in h |
SWISS |
P02647 |
Gene ID |
335 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Apolipoprotein A I promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A I is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77 amino acids; an 18 amino acid signal peptide is removed co-translationally and a 6 amino acid propeptide is cleaved post-translationally. Apolipoprotein A I is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. Defects in the Apolipoprotein A I gene are associated with HDL deficiency and Tangier disease. The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I. The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases. |