货号 |
bs-12155R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-phospho-Cyclin D3 (Thr283) antibody |
中文名称 |
Rabbit Anti-phospho-Cyclin D3 (Thr283) antibody |
产品标签 |
磷酸化抗体 |
研究领域 |
肿瘤,细胞生物,染色质和核信号,细胞周期蛋白,表观遗传学, |
英文别名 |
Cyclin D3 (phospho T283); Cyclin D3 (phospho Thr283); p-Cyclin D3 (T283); p-Cyclin D3 (Thr283); p-Cyclin D3 (phospho T283); CCND 3; Ccnd3; CCND3_HUMAN; CyclinD3; D3 type cyclin; G1 S specific cyclin D3; G1/S specific cyclin D3; G1/S-specific cyclin-D3. |
反应物种(已验证) |
Human |
反应物种(预测) |
Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep |
产品应用(已验证) |
ICC,FCM |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
Elisa=1:5000-10000,Flow Cyt=1ug/Test,ICC=1:100, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
33 |
细胞定位 |
细胞核,细胞浆,细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthesised phosphopeptide derived from human Cyclin D3 around the phosphorylation site of Thr283 |
抗原表位 |
TS(p-T)PT |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Nucleus. Cytoplasm. Membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. |
SIMILARITY |
Belongs to the cyclin family. Cyclin D subfamily.
Contains 1 cyclin N-terminal domain. |
SUBUNIT |
Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K. Component of the ternary complex cyclin D/CD |
Function |
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of t |
Post-translational |
Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation. |
SWISS |
P30281 |
Gene ID |
896 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]. |