货号 |
bs-8486R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-FNDC5 antibody |
中文名称 |
Rabbit Anti-FNDC5 antibody |
研究领域 |
细胞生物,新陈代谢, |
英文别名 |
Fibronectin type III domain containing 5; Fibronectin type III domain-containing protein 5; Fibronectin type III repeat containing protein 2; Fibronectin type III repeat-containing protein 2; FNDC 5; FNDC5_HUMAN; FRCP2; Irisin. |
反应物种(已验证) |
Human,Mouse |
反应物种(预测) |
Rat,Chicken,Dog,Rabbit |
产品应用(已验证) |
WB,IHC |
产品应用(可推荐) |
ICC,IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200,ICC=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
12/20 |
细胞定位 |
细胞浆,细胞膜,分泌型蛋白 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human FNDC5 |
抗原表位 |
81-143/212 |
抗原细胞定位 |
Extracellular |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cell membrane; Single-pass type I membrane protein. Peroxisome membrane; Single-pass type I membrane protein. Note=Imported in peroxisomes through the PEX5 receptor pathway. Irisin: Secreted. Note=Detected in the blood of individuals subjected to endur |
SIMILARITY |
Contains 1 fibronectin type-III domain. |
Function |
Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. |
Post-translational |
The extracellular domain is cleaved and released from the cell membrane. N-Glycosylated. |
SWISS |
Q8NAU1 |
Gene ID |
252995 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]. |