免 疫 原：KLH conjugated synthetic peptide derived from human FNDC5
抗原表位：81-143/212
抗原细胞定位：Extracellular
SWISS：Q8NAU1
Gene ID ：252995
Human Gene ID：252995

This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].
Function：Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA.
Subcellular Location：Cell membrane; Single-pass type I membrane protein. Peroxisome membrane; Single-pass type I membrane protein. Note=Imported in peroxisomes through the PEX5 receptor pathway.
Irisin: Secreted. Note=Detected in the blood of individuals subjected to endur
Post-translational modifications：The extracellular domain is cleaved and released from the cell membrane.
N-Glycosylated.
Similarity：Contains 1 fibronectin type-III domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.