货号 |
bs-6329R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-NTR3 antibody |
中文名称 |
Rabbit Anti-NTR3 antibody |
研究领域 |
心血管,细胞生物,免疫学,神经生物学,细胞凋亡 |
英文别名 |
100 kDa NT receptor; Glycoprotein 95; Gp 95; Gp95; Neurotensin receptor 3; NT 3; NT3; NTR 3; NTR3; SORT 1; SORT_HUMAN; SORT1 (gene name); SORT1; Sortilin 1; Sortilin; Sortilin1. |
反应物种(已验证) |
Mouse,Rat |
反应物种(预测) |
Human,Dog,Pig,Cow,Horse,GuineaPig |
产品应用(已验证) |
WB,IHC |
产品应用(可推荐) |
IF,ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
84 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human Sortilin/NTR3/Gp95 |
抗原表位 |
731-831/831 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Membrane; Single-pass type I membraneprotein. Endoplasmic reticulum membrane; Single-pass type Imembrane protein (Potential). Endosome membrane; Single-pass type Imembrane protein (Potential). Golgi apparatus, Golgi stackmembrane; Single-pass type I membr |
Tissue |
Expressed at high levels in brain, spinalcord, heart, skeletal muscle, thyroid, placenta and testis.Expressed at lower levels in lymphoid organs, kidney, colon andliver. |
SIMILARITY |
Belongs to the VPS10-related sortilin family. SORT1subfamily. Contains 9 BNR repeats. |
SUBUNIT |
Interacts with LPL and SLC2A4 (By similarity). Interactswith the cytosolic adapter proteins GGA1 and GGA2. Interacts withnumerous ligands including the receptor-associated proteinLRPAP1/RAP, GM2A, NTS and PSAP. Forms a complex with NGFR whichbinds specifi |
Function |
Functions as a sorting receptor in the Golgi compartmentand as a clearance receptor on the cell surface. Required forprotein transport from the Golgi apparatus to the lysosomes by apathway that is independent of the mannose-6-phosphate receptor(M6PR). Als |
Post-translational |
The N-terminal propeptide is cleaved by furin and possiblyother homologous proteases. |
DISEASE |
Note=A common polymorphism located in a non-coding regionbetween CELSR2 and PSRC1 alters a CEBP transcription factor bindingsite and is responsible for changes in hepatic expression of SORT1.Altered SORT1 expression in liver affects low density lipoprotei |
SWISS |
Q99523 |
Gene ID |
6272 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.
Tissue specificity: Expressed at high levels in brain, spinal cord, heart, skeletal muscle, thyroid, placenta and testis. Expressed at lower levels in lymphoid organs, kidney, colon and liver. |