货号 |
bs-11831R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-Chordin antibody |
中文名称 |
Rabbit Anti-Chordin antibody |
研究领域 |
细胞生物,发育生物学,神经生物学,干细胞 |
英文别名 |
Chordin; Chrd; CHRD_HUMAN; MGC133038; Shortgastrulation protein; SOG. |
反应物种(预测) |
Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep |
产品应用(已验证) |
WB |
产品应用(可推荐) |
ELISA |
推荐稀释比例 |
WB=1:500-2000,Elisa=1:5000-10000, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
99 |
细胞定位 |
分泌型蛋白 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human Chordin |
抗原表位 |
412-490/951 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Secreted. |
Tissue |
Expressed at the highest level in liver. |
SIMILARITY |
Belongs to the chordin family.
Contains 4 CHRD domains.
Contains 4 VWFC domains. |
SUBUNIT |
Interacts with TWSG1 and/or BMP4 |
Function |
Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. |
Post-translational |
Cleaved by tolloid proteases; cleavage participates to dorsoventral patterning during early development. |
SWISS |
Q9H2X0 |
Gene ID |
8646 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The patterning of the CNS relies on the interaction of multiple signaling molecules such as Sonic Hedgehog, Wnts, and BMPs and their antagonists Chordin and Noggin. At midgastrula, expression of Noggin overlaps that of Chordin. Chordin is a key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The gene which encodeschordin maps to human chromosome 3q27. Noggin is a secreted protein that binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily of signaling proteins, such as BMP-2,4,7. The gene which encodes noggin maps to human chromosome 17q22. |