免 疫 原：KLH conjugated synthetic peptide derived from human Chordin
抗原表位：412-490/951
SWISS：Q9H2X0
Gene ID ：8646
Human Gene ID：8646

The patterning of the CNS relies on the interaction of multiple signaling molecules such as Sonic Hedgehog, Wnts, and BMPs and their antagonists Chordin and Noggin. At midgastrula, expression of Noggin overlaps that of Chordin. Chordin is a key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The gene which encodeschordin maps to human chromosome 3q27. Noggin is a secreted protein that binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily of signaling proteins, such as BMP-2,4,7. The gene which encodes noggin maps to human chromosome 17q22.
Function：Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
Subunit：Interacts with TWSG1 and/or BMP4
Subcellular Location：Secreted.
Tissue Specificity：Expressed at the highest level in liver.
Post-translational modifications：Cleaved by tolloid proteases; cleavage participates to dorsoventral patterning during early development.
Similarity：Belongs to the chordin family.
Contains 4 CHRD domains.
Contains 4 VWFC domains.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.