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货号 | bs-12709R-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Rabbit Anti-phospho-IRS1 (Ser323) antibody |
中文名称 | Rabbit Anti-phospho-IRS1 (Ser323) antibody |
产品标签 | 磷酸化抗体 |
研究领域 | 肿瘤,细胞生物,免疫学,神经生物学,糖尿病,细胞膜蛋白, |
英文别名 | IRS1 (phospho S323); p-IRS1 (phospho S323); HIRS 1; IRS1_HUMAN; Insulin receptor substrate 1; IRS-1; IRS 1; |
反应物种(已验证) | Human,Mouse |
反应物种(预测) | Rat,Rabbit |
产品应用(已验证) | IHC,FCM |
产品应用(可推荐) | WB,IF |
推荐稀释比例 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=1μg/Test,IF=1:100-500, |
克隆类型 | 多克隆 |
抗体来源 | Rabbit |
理论分子量 | 132 |
细胞定位 | 细胞膜 |
性状 | Liquid |
免疫原 | KLH conjugated synthesised phosphopeptide derived from human IRS1 around the phosphorylation site of Ser323 |
抗原表位 | PG(p-S)FR |
亚型 | IgG |
纯化方法 | affinity purified by Protein A |
SUBCELLULAR | Membrane; Single-pass type I membrane protein. |
Tissue | Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vasc |
SIMILARITY | Contains 1 IRS-type PTB domain. Contains 1 PH domain. |
Function | May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosp |
Post-translational | Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor. Phosphorylation of Tyr-896 is required for GRB2-binding. |
DISEASE | The gene represented in this entry may be involved in disease pathogenesis. Disease description:A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body |
SWISS | P35568 |
Gene ID | 3667 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009] |