货号 |
bs-18726R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-phospho-MCL1 (Ser159) antibody |
中文名称 |
Rabbit Anti-phospho-MCL1 (Ser159) antibody |
产品标签 |
磷酸化抗体 |
研究领域 |
肿瘤,细胞生物,信号转导,细胞凋亡,线抗体, |
英文别名 |
MCL1 (phospho S159); p-MCL1 (phospho S159);
Bcl 2 related protein EAT/mcl1;
Bcl-2-like protein 3;
Bcl-2-related protein EAT/mcl1;
BCL2 related;
Bcl2-L-3;
BCL2L3;
EAT;
Induced myeloid leukemia cell differentiation protein Mcl 1;
Induced myeloid leu |
反应物种(已验证) |
Human,Mouse |
反应物种(预测) |
Rat,Pig,Horse,Rabbit |
产品应用(已验证) |
WB,IHC |
推荐稀释比例 |
WB=1:500-2000,IHC-P=1:100-500, |
克隆类型 |
多克隆 |
抗体来源 |
Rabbit |
理论分子量 |
37 |
细胞定位 |
细胞浆,细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthesised phosphopeptide derived from human Mcl 1 around the phosphorylation site of Ser159. |
抗原表位 |
DG(p-S)LP |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Membrane. Cytoplasm. Mitochondrion. Nucleus > nucleoplasm. Cytoplasmic, associated with mitochondria. |
SIMILARITY |
Belongs to the Bcl-2 family. |
Function |
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promot |
SWISS |
Q07820 |
Gene ID |
4170 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Mcl1 is an anti-apoptotic member of Bcl2 family originally isolated from the ML1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Mcl1 localizes to the mitochondria, interacts with and antagonizes pro-apoptotic Bcl2 family members, and inhibits apoptosis by a number of cytotoxic stimuli. It is involved in programing of differentiation and concomitant maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes it. Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML1. |