| Rabbit Anti-phospho-MCL1 (Ser159) antibody |
| 反应物种（预测） |
Rat,Pig,Horse,Rabbit |
| 产品应用（已验证） |
WB,IHC |
| 推荐稀释比例 |
WB=1:500-2000,IHC-P=1:100-500, |
| 研究领域 |
肿瘤,细胞生物,信号转导,细胞凋亡,线抗体, |
| 标签 |
Array |
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Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (phospho-MCL1 (Ser159)) Polyclonal Antibody, Unconjugated (bs-18726R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
RRID：RRID
产品名称：Rabbit Anti-phospho-MCL1 (Ser159) antibody
别名： MCL1 (phospho S159); p-MCL1 (phospho S159);
Bcl 2 related protein EAT/mcl1;
Bcl-2-like protein 3;
Bcl-2-related protein EAT/mcl1;
BCL2 related;
Bcl2-L-3;
BCL2L3;
EAT;
Induced myeloid leukemia cell differentiation protein Mcl 1;
Induced myeloid leu
中文名称：磷酸化髓样细胞白血病1抗体
英文名称：Rabbit Anti-phospho-MCL1 (Ser159) antibody
抗体来源： Rabbit
克隆类型：多克隆
细胞定位：细胞浆,细胞膜
性 状：Liquid
亚 型：IgG
纯化方法：affinity purified by Protein A
保存条件：Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原：KLH conjugated synthesised phosphopeptide derived from human Mcl 1 around the phosphorylation site of Ser159.
抗原表位：DG(p-S)LP
SWISS：Q07820
Gene ID ：4170
Human Gene ID：4170
Mcl1 is an anti-apoptotic member of Bcl2 family originally isolated from the ML1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Mcl1 localizes to the mitochondria, interacts with and antagonizes pro-apoptotic Bcl2 family members, and inhibits apoptosis by a number of cytotoxic stimuli. It is involved in programing of differentiation and concomitant maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes it. Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML1.
Function：Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promot
Subcellular Location：Membrane. Cytoplasm. Mitochondrion. Nucleus > nucleoplasm. Cytoplasmic, associated with mitochondria.
Similarity：Belongs to the Bcl-2 family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
400-901-9800
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