货号 |
bsm-33041M-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Mouse Anti-beta I Tubulin (Loading Control) antibody |
中文名称 |
Mouse Anti-beta I Tubulin (Loading Control) antibody |
产品标签 |
内参抗体 |
研究领域 |
细胞生物,免疫学,信号转导,细胞骨架, |
英文别名 |
2810484G07Rik;
Beta tubulin 1, class VI;
Class VI beta tubulin;
dJ543J19.4;
M(beta)1;
TBB1_HUMAN;
TUBB1;
Tubulin beta 1 class VI;
Tubulin beta-1 chain;
Tubulin, beta 1;
tubulin, beta1; |
反应物种(已验证) |
Human,Mouse,Rat |
产品应用(已验证) |
WB,IHC,ICC,FCM |
产品应用(可推荐) |
IF |
推荐稀释比例 |
WB=1:5000-20000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=1:100-500,IF=1:100-500,ICC=1:100-500, |
克隆类型 |
单克隆 |
克隆号 |
5F7 |
抗体来源 |
Mouse |
理论分子量 |
50 |
细胞定位 |
细胞浆 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human beta I Tubulin |
亚型 |
IgG2a |
纯化方法 |
affinity purified by Protein G |
SUBCELLULAR |
Cytoplasm, cytoskeleton |
Tissue |
Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins. |
SIMILARITY |
Belongs to the tubulin family. |
SUBUNIT |
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtub |
Function |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). |
Post-translational |
Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes |
DISEASE |
Macrothrombocytopenia, autosomal dominant, TUBB1-related (MAD-TUBB1). The disease is caused by mutations affecting the gene represented in this entry. A congenital blood disorder characterized by increased platelet size and decreased number of circulating |
SWISS |
Q9H4B7 |
Gene ID |
81027 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.[provided by RefSeq, Jul 2010] |