货号 |
bsm-51267M-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Mouse Anti-SOD2 antibody |
中文名称 |
Mouse Anti-SOD2 antibody |
研究领域 |
神经生物学,细胞凋亡,激酶和磷酸酶,线抗体, |
英文别名 |
IPO B; Manganese SOD; Superoxide Dismutase 2; Manganese superoxide dismutase; Mn SOD; MNSOD; SOD 2; SOD-2; SOD2; Superoxide dismutase [Mn] mitochondrial; Superoxide dismutase [Mn] mitochondrial precursor; Superoxide dismutase 2 mitochondrial; SODM_HUMAN. |
反应物种(已验证) |
Human,Mouse |
产品应用(已验证) |
WB,IHC |
产品应用(可推荐) |
IF |
推荐稀释比例 |
WB=1:200-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:20-200, |
克隆类型 |
单克隆 |
克隆号 |
6C11 |
抗体来源 |
Mouse |
理论分子量 |
22 |
细胞定位 |
细胞浆 |
性状 |
Liquid |
免疫原 |
Recombinant human SOD protein |
亚型 |
IgG1κ |
纯化方法 |
affinity purified by Protein G |
SUBCELLULAR |
Mitochondrion matrix. |
SIMILARITY |
Belongs to the iron/manganese superoxide dismutase family. |
SUBUNIT |
Homotetramer. |
Function |
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. |
Post-translational |
Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting. |
DISEASE |
Microvascular complications of diabetes 6 (MVCD6) [MIM:612634]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal d |
SWISS |
P04179 |
Gene ID |
6648 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |