免 疫 原：Recombinant human SOD protein
SWISS：P04179
Gene ID ：6648
Human Gene ID：6648

This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Function：Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Subunit：Homotetramer.
Subcellular Location：Mitochondrion matrix.
Post-translational modifications：Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting.
DISEASE：Microvascular complications of diabetes 6 (MVCD6) [MIM:612634]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal d
Similarity：Belongs to the iron/manganese superoxide dismutase family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.