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货号 | bsm-30078M-APC-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Mouse Anti-human CD33-APC antibody |
中文名称 | Mouse Anti-human CD33-APC antibody |
研究领域 | 免疫学,干细胞,细胞表面分子, |
英文别名 | CD33_HUMAN; CD 33; CD33 antigen; CD33 molecule; FLJ00391; gp67 ; Myeloid cell surface antigen CD33; Myeloid cell surface antigen CD33 precursor; p67 ; Sialic acid binding Ig like lectin 3; Sialic acid binding immunoglobulin like lectin 3; SIGLEC3; Siglec- |
中文别名 | APC anti-human CD33; |
反应物种(已验证) | Human |
产品应用(已验证) | FCM |
推荐稀释比例 | Flow Cyt=5ul/Test, |
克隆类型 | 单克隆 |
克隆号 | HI33a |
抗体来源 | Mouse |
理论分子量 | 40/37 |
细胞定位 | 细胞膜 |
性状 | Liquid |
亚型 | IgG2a |
纯化方法 | affinity purified by Protein G |
SUBCELLULAR | Cell membrane; Single-pass type I membrane protein. |
Tissue | Monocytic/myeloid lineage cells. |
SIMILARITY | Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
SUBUNIT | Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation. |
Function | Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on |
Post-translational | Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6. |
SWISS | P20138 |
Gene ID | 945 |
保存条件 | Store at 2-8℃ for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells. The protein is also expressed on, and is a useful marker for, peripheral monocytes. It is also useful for distinguishing myelogenous leukaemia cells from lymphoid or erythroid leukaemias. |