货号 |
bsm-30098M-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Mouse Anti-human CD20 antibody |
中文名称 |
Mouse Anti-human CD20 antibody |
研究领域 |
肿瘤,免疫学,干细胞,细胞表面分子,B-淋巴细胞, |
英文别名 |
CD20_HUMAN; B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; MS4A1; MS4A2; B1; CVID5; LEU-16; S7. |
反应物种(预测) |
Human |
产品应用(已验证) |
FCM |
克隆类型 |
单克隆 |
克隆号 |
HI20a |
抗体来源 |
Mouse |
理论分子量 |
33 |
细胞定位 |
细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human CD20 |
亚型 |
Mouse IgG2a |
纯化方法 |
Affinity purified by Protein G |
SUBCELLULAR |
Membrane; Multi-pass membrane protein. |
Tissue |
Expressed on B-cells. |
SIMILARITY |
Belongs to the MS4A family. |
Function |
This protein may be involved in the regulation of B-cell activation and proliferation |
Post-translational |
Phosphorylated. Might be functionally regulated by protein kinase(s). |
DISEASE |
Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent |
SWISS |
P11836 |
保存条件 |
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
CD20 is a non glycosylated protein with a molecular weight of 35 or 37 kDa depending on the degree of phosphorylation. Although not a member of the tetraspanin superfamily of cell surface receptors, it crosses the cell membrane four times. The CD20 antigen is present on human pre B lymphocytes and on B lymphocytes at all stages of maturation, except on plasma cells. Low level expression of the CD20 antigen has been detected on normal T lymphocytes. The CD20 molecule is involved in regulation of B cell differentiation, presumably via its reported function as a Ca++ channel subunit. |