免 疫 原：KLH conjugated synthetic peptide derived from human CD20
SWISS：P11836

CD20 is a non glycosylated protein with a molecular weight of 35 or 37 kDa depending on the degree of phosphorylation. Although not a member of the tetraspanin superfamily of cell surface receptors, it crosses the cell membrane four times. The CD20 antigen is present on human pre B lymphocytes and on B lymphocytes at all stages of maturation, except on plasma cells. Low level expression of the CD20 antigen has been detected on normal T lymphocytes. The CD20 molecule is involved in regulation of B cell differentiation, presumably via its reported function as a Ca++ channel subunit.
Function：This protein may be involved in the regulation of B-cell activation and proliferation
Subcellular Location：Membrane; Multi-pass membrane protein.
Tissue Specificity：Expressed on B-cells.
Post-translational modifications：Phosphorylated. Might be functionally regulated by protein kinase(s).
DISEASE：Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent
Similarity：Belongs to the MS4A family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.