货号 |
bsm-51301M-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Mouse Anti-LAMP1 antibody |
中文名称 |
Mouse Anti-LAMP1 antibody |
研究领域 |
肿瘤,免疫学,神经生物学,信号转导,干细胞,新陈代谢,细胞类型标志物(Lysosome Marker), |
英文别名 |
CD107 antigen like family member A; CD107 antigen-like family member A; CD107a; CD107a antigen; LAMP 1; LAMP-1; LAMP1_HUMAN; LAMPA; LGP120; lgpA; Lysosomal membrane glycoprotein 120KD; Lysosomal Associated Membrane Protein 1; Lysosome associated membrane |
反应物种(已验证) |
Human |
反应物种(预测) |
African Green Monkey |
产品应用(已验证) |
WB |
产品应用(可推荐) |
IHC,ICC,IF,ELISA |
推荐稀释比例 |
WB=1:500-1000,Elisa=1:5000-10000,IHC-P=1:50-300,IHC-F=1:50-300,IF=1:20-200,ICC=1:20-200, |
克隆类型 |
单克隆 |
克隆号 |
2C5 |
抗体来源 |
Mouse |
理论分子量 |
42 |
细胞定位 |
细胞浆,细胞膜 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human LAMP1 |
亚型 |
IgG1,k |
纯化方法 |
affinity purified by Protein G |
SUBCELLULAR |
Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane. |
SIMILARITY |
Belongs to the LAMP family. |
Function |
Presents carbohydrate ligands to selectins. Also mplicated in tumor cell metastasis. |
Post-translational |
O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. |
SWISS |
P11279 |
Gene ID |
3916 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation. |