免 疫 原：KLH conjugated synthetic peptide derived from human LAMP1
SWISS：P11279
Gene ID ：3916
Human Gene ID：3916

Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.
Function：Presents carbohydrate ligands to selectins. Also mplicated in tumor cell metastasis.
Subcellular Location：Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane.
Post-translational modifications：O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans.
Similarity：Belongs to the LAMP family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.