货号 |
bsm-52239R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-STAT6 antibody |
中文名称 |
Rabbit Anti-STAT6 antibody |
产品标签 |
重组兔单抗 |
研究领域 |
肿瘤,发育生物学,信号转导,细胞凋亡,转录调节因子,表观遗传学, |
英文别名 |
signal transducers and activators of transduction 6; D12S1644; IL 4 STAT; IL4 STAT; Interleukin 4 Induced; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced; Signal Transducer And |
反应物种(已验证) |
Human,Mouse |
产品应用(已验证) |
WB,FCM |
产品应用(可推荐) |
IHC,ICC,IF |
推荐稀释比例 |
WB=1:500-1000,IHC-P=1:20-200,IHC-F=1:20-200,Flow Cyt=2ug/Test,IF=1:20-200,ICC=1:20-200, |
克隆类型 |
单克隆 |
克隆号 |
9A7 |
抗体来源 |
Rabbit |
理论分子量 |
94 |
细胞定位 |
细胞核,细胞浆 |
性状 |
Liquid |
免疫原 |
Recombinant human STAT6 protein, around 700-800aa |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation. |
SIMILARITY |
Belongs to the transcription factor STAT family.
Contains 1 SH2 domain. |
SUBUNIT |
Forms a homodimer or a heterodimer with a related family member. Interacts with NCOA1 via its C-terminal LXXLL motif. |
Function |
Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling. |
Post-translational |
Tyrosine phosphorylated following stimulation by IL-4 and IL-3. |
SWISS |
P42226 |
Gene ID |
6778 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. |