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货号 | bsm-52218R-1 |
品牌 | |
浓度 | |
货期 | 现货 |
英文名称 | Rabbit Anti-PI3-kinase p110 subunit beta antibody |
中文名称 | Rabbit Anti-PI3-kinase p110 subunit beta antibody |
产品标签 | 重组兔单抗 |
研究领域 | 肿瘤,细胞生物,免疫学,信号转导,细胞周期蛋白,激酶和磷酸酶 |
英文别名 | PI3-kinase p110 subunit beta; p110 BETA; p110Beta; PI3K beta; Phosphatidylinositol 3 kinase catalytic beta polypeptide; Phosphatidylinositol 4 5 bisphosphate 3 kinase 110 kDa catalytic subunit beta; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic |
反应物种(已验证) | Human |
产品应用(已验证) | WB |
产品应用(可推荐) | IP |
推荐稀释比例 | WB=1:500-2000,IP=1:20-50, |
克隆类型 | 单克隆 |
克隆号 | 34F12 |
抗体来源 | Rabbit |
理论分子量 | 123 |
细胞定位 | 细胞核,细胞浆 |
性状 | Liquid |
免疫原 | Recombinant human PI3-kinase p110 subunit beta protein, around C-terminal 150aa |
亚型 | IgG |
纯化方法 | affinity purified by Protein A |
SUBCELLULAR | Cytoplasm. Nucleus. Note=Interaction with PIK3R2 is required for nuclear localization and export. |
Tissue | Expressed ubiquitously. |
SIMILARITY | Belongs to the PI3/PI4-kinase family. Contains 1 C2 PI3K-type domain. Contains 1 PI3K-ABD domain. Contains 1 PI3K-RBD domain. Contains 1 PI3K/PI4K domain. Contains 1 PIK helical domain. |
SUBUNIT | PIK3R2 or PIK3R3). Interaction with PIK3R2 is required for nuclear localization and nuclear export. Part of a complex with PIK3R1 and PTEN. Binding to PTEN may antagonize the lipid kinase activity under normal growth conditions. Part of a complex involved |
Function | Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 pla |
Post-translational | Phosphorylation at Ser-1070 down-regulates lipid kinase activity. |
SWISS | P42338 |
Gene ID | 5291 |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 | This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]. |