Rabbit Anti-PI3-kinase p110 subunit beta antibody |
产品应用(已验证) |
WB |
产品应用(可尝试) |
IP |
推荐稀释比例 |
WB=1:500-2000,IP=1:20-50, |
研究领域 |
肿瘤,细胞生物,免疫学,信号转导,细胞周期蛋白,激酶和磷酸酶 |
标签 |
Array |
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Sample:
Lane 1: Human MCF-7 cell lysates
Lane 2: Human K562 cell lysates
Lane 3: Human Jurkat cell lysates
Primary: Anti-PI3-kinase p110 subunit beta (bsm-52218R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 123 kD
Observed band size: 110 kD
RRID:RRID
产品名称:Rabbit Anti-PI3-kinase p110 subunit beta antibody
别名: PI3-kinase p110 subunit beta; p110 BETA; p110Beta; PI3K beta; Phosphatidylinositol 3 kinase catalytic beta polypeptide; Phosphatidylinositol 4 5 bisphosphate 3 kinase 110 kDa catalytic subunit beta; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic
中文名称:磷脂酰肌醇激酶(PI3Kβ)重组兔单克隆抗体
英文名称:Rabbit Anti-PI3-kinase p110 subunit beta antibody
抗体来源: Rabbit
克隆类型:单克隆
细胞定位:细胞核,细胞浆
性 状:Liquid
亚 型:IgG
纯化方法:affinity purified by Protein A
保存条件:Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原:Recombinant human PI3-kinase p110 subunit beta protein, around C-terminal 150aa
SWISS:P42338
Gene ID :5291
Human Gene ID:5291
This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011].
Function:Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 pla
Subunit:PIK3R2 or PIK3R3). Interaction with PIK3R2 is required for nuclear localization and nuclear export. Part of a complex with PIK3R1 and PTEN. Binding to PTEN may antagonize the lipid kinase activity under normal growth conditions. Part of a complex involved
Subcellular Location:Cytoplasm. Nucleus. Note=Interaction with PIK3R2 is required for nuclear localization and export.
Tissue Specificity:Expressed ubiquitously.
Post-translational modifications:Phosphorylation at Ser-1070 down-regulates lipid kinase activity.
Similarity:Belongs to the PI3/PI4-kinase family.
Contains 1 C2 PI3K-type domain.
Contains 1 PI3K-ABD domain.
Contains 1 PI3K-RBD domain.
Contains 1 PI3K/PI4K domain.
Contains 1 PIK helical domain.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.