货号 |
bsm-52594R-1 |
品牌 |
|
浓度 |
|
货期 |
现货 |
英文名称 |
Rabbit Anti-AGR2 antibody |
中文名称 |
Rabbit Anti-AGR2 antibody |
产品标签 |
重组兔单抗 |
研究领域 |
肿瘤,细胞生物,免疫学,转录调节因子 |
英文别名 |
HAG2; AG2 protein; hAG2; Secreted cement gland protein XAG2 homolog; AG 2; AG 2 protein; AG-2; AG2; AG2 protein; AGR 2; AGR2; AGR2_HUMAN; Anterior gradient 2 homolog (Xenopus laevis); anterior gradient 2 homolog; Anterior gradient protein 2 homolog; GOB 4 |
反应物种(已验证) |
Human |
产品应用(已验证) |
WB,IHC |
产品应用(可推荐) |
ICC,IP |
推荐稀释比例 |
WB=1:1000-5000,IP=1:20-100,IHC-P=1:50-200,IHC-F=1:50-200,ICC=1:50-200, |
克隆类型 |
单克隆 |
克隆号 |
3F8 |
抗体来源 |
Rabbit |
理论分子量 |
20 |
细胞定位 |
细胞浆,分泌型蛋白 |
性状 |
Liquid |
免疫原 |
KLH conjugated synthetic peptide derived from human AGR2 |
亚型 |
IgG |
纯化方法 |
affinity purified by Protein A |
SUBCELLULAR |
Secreted. Endoplasmic reticulum. |
Tissue |
Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid |
SIMILARITY |
Belongs to the AGR family. |
SUBUNIT |
Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked. |
Function |
Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. |
SWISS |
O95994 |
Gene ID |
10551 |
保存条件 |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
Important Note |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
英文介绍 |
AGR2 is a member of the anterior gradient homolog family. It is the human ortholog of XAG-2, the secreted Xenopus laevis Anterior Gradient protein. In X. laevis, it is involved in cement gland differentiation and neural marker gene expression. AGR2 is a secretory protein encoded by two different AGR2 transcripts. It interacts with LYPD3 and ?dystroglycan (DAG-1). AGR2 is ubiquitously expressed with up-regulated expression in prostate cancer, breast cancer, lung cancer, renal carcinomas and endometrial carcinomas. AGR2 expression is positively correlated with that of the estrogen receptor (ER) and is negatively correlated with that of the epidermal growth factor receptor (EGFR). AGR2 may serve as a potential therapeutic marker for various cancers. |